Researchers find bacterial toxin with healing effect

Did you know a bacterial toxin could promote tissue healing? Yes, the compound found in Staphylococcus aureus does not just damage cells; it even stimulates tissue regeneration.

Normally they are among the many harmless orgsms found in and on the human body: one in four people have millions of Staphylococcus aureus bacteria on their skin and the mucous membranes of the upper respiratory tract, without being aware of it. In some cases, however, the harmless bacteria can turn into pathogens, which can lead to skin inflammation and lung infections, or -- in the worst cases -- sepsis. "This happens especially when the bacteria multiply too fast, for example when a person's immune system is weakened by an infection or injury," says Prof. Oliver Werz of Friedrich Schiller University Jena in Germany.

The pharmaceutical chemistry professor and his team have studied the molecular defence mechsms of the human immune system in the fight against such Staphylococcus aureus infections and made the surprising discovery.

As the research team reports in the current issue of the specialist journal, Cell Reports, the toxic cocktail, with which Staphylococcus aureus damages cells and tissues, also have positive effects: specific immune cells are stimulated by the bacterial toxin to produce specialised messenger substances that help in reducing inflammation and promoting tissue healing.

Prof. Werz expects this hitherto unknown mechsm to be significant for future treatments of skin inflammation and chronic wounds.

In their latest study, the researchers from the University of Jena, Jena University Hospital, and the Leibniz Institute on Aging -- Fritz Lipmann Institute (FLI), together with colleagues from Harvard Medical School and the University of Naples, have studied in particular the bacterial toxin "Hemolysin" and examined its effect on M2 macrophages. The M2 macrophages are immune cells, which in the later stages of an inflammatory reaction, ensure that the bacteria that have been killed, and that have damaged cell components, are removed and that the tissue regenerates. "They are therefore a kind of cellular waste disposal," says Paul Jordan, a doctoral candidate in Werz's team and lead author of the publication, describing the function of these cells.

The researchers showed that Hemolysin binds to specific receptor proteins on the surface of M2 macrophages and thus triggers the production of anti-inflammatory messenger substances in the cells, which then cause the inflammation to resolve.

In the study, the scientists were also able to show that these transmitters promote tissue regeneration in an mal model. The anti-inflammatory messenger substances include resolvins, maresins and protectins that are generated from omega-3 fatty acids.

( With inputs from ANI )