Study explores link between infant antibiotic exposure, future immune responses toward allergies

An irreversible loss of regulatory T-cells in the colon is found in infants who were exposed to antibiotics in utero and infancy. T cells are a valuable component of the immune system's response toward allergens in later life, after only six months.

The findings of the study were published in the journal mBio.

It is already known that the use of antibiotics early in life disrupts the intestinal microbiota - the trillions of beneficial microorgsms that live in and on our bodies - that play a crucial role in the healthy maturation of the immune system and the prevention of diseases, such as obesity and inflammatory bowel disease.

However, less is known about how disruption of the microbiota, which produces short-chain fatty acids that regulate T-cells, affects T-cells in the colon.

The study, based on a mouse model, looked at fetal and newborn exposure to antibiotics through the mother in the weeks immediately preceding and after birth, the time when microbial communities assemble and are prone to disruptions, to investigate how this reduction in beneficial bacteria affects neonatal immune system development.

These effects were specific to the colon and not observed in the lungs, upper gastrointestinal tract, or spleen."By studying the exposure to newborns through lactating mothers, we see how the offspring acquire their mothers' antibiotic-impacted microbiota, which compromises their ability to generate a pool of CD41 T cells in the colon, resulting in long-term damage," said co-author Martin Blaser, director of the Center for Advanced Biotechnology and Medicine at Rutgers.

"The consequences persist into adulthood, compromising the body's ability to turn off allergic responses," Blaser concluded.

( With inputs from ANI )