Faseb, Non-profit organization

Washington D.C. [USA], Mar 23 : In a breakthrough study, researchers have identified a mechsm that drives the clearance of damaged mitochondria. The discovery can be considered to take researchers one step closer in the field of drug therapies that help older adults maintain their skeletal muscle mass and physical function for longer.A team in the University's School of Sport, Exercise and Rehabilitation Sciences are well-versed at investigating dynamic machinery within cells called mitochondria. Mitochondria act as the power plant in every cell and help to supply energy for all living things.Because mitochondria are so important to energy supply, they constantly undergo synthesis and break down to match energy demands. However, in older people, the way that mitochondria are naturally broken down in cells starts to change, leading to a build-up of damaged mitochondria or old mitochondria that are not functioning as well.It is thought these changes might contribute to the decline in the function of older people's muscles, which in turn reduces their physical capabilities. The team wanted to find out more about the mitochondrial break down in muscle and the factors controlling it. Their results are published in the journal FASEB.The lead researcher Alex Seabright (PhD candidate in the Lai lab) developed a new tool that uses fluorescent tags to study the mitochondria in muscle cells. In healthy cells, networks of mitochondria appear gold in colour but turn red when undergoing break down.Using this experimental setup, they discovered that activating a master energy sensor molecule, called AMP-activated protein kinase (AMPK), helps to stimulate mitochondrial breakdown. These exciting findings suggest that other well-known AMPK activators, such as exercise, may stimulate the clearance of damaged mitochondria, thus keeping mitochondria in muscle healthy and prolonging older people's physical capabilities.Project Leader Dr Yu-Chiang Lai says: "The idea of targeting AMPK with drugs is not new. Many studies, including some of our previous work, demonstrate that AMPK activation in muscle elicits many beneficial effects for treating type 2 diabetes."As a consequence, many pharmaceutical compes are currently working to develop pre-clinical compounds that activate AMPK. We hope that our new discovery will accelerate targeted drug development to help identify new and safe compounds to activate this key molecule in muscle.Alex Seabright adds: "We know that exercise and diet regimes can be used to help people maintain their muscle mass and physical capabilities in later life. But, improving our understanding as to why muscle loss occurs with ageing, will aid the development of targeted pharmacological interventions to help people to stay physically capable for longer."( With inputs from ANI )

Home

City

Latest News

Cricket

LT Premium

National

International

Maharashtra

Opinions

Chhatrapati Sambhajinagar

Nagpur

Entertainment

Photos

Business

Technology

Sports

Lifestyle

Social Viral

Lokmat Games

Health

Lok Sabha Election 2024

Heatwave In India

Mumbai Water Cut

Maharashtra Lok Sabha Election

IPL 2024

Salman Khan

FasebFOLLOW

Faseb, Latest News

Technology :Study gives insight into mechanism of body's regulation of salt balance

Washington [US], April 3 : An innovative mechsm of the body's regulation of salt balance is the topic of ... ...

Health :Study sheds new insights into how body handles salt

Huntington [US], March 31 : A new study led by Marshall University academics focuses on a unique mechsm for ... ...

International :Has China managed to hide the real source of COVID-19: Tsering Passang questions International Community

Founder of Global Alliance for Tibet and Persecuted Minorities (GATPM), Tsering Passang questioned the international community if it has failed to get to the bottom of the real source of COVID-19 or has China successfully managed to cover it up. ...

Health :New research may help the elderly to stay physically strong for longer period

A new study has discovered a mechanism that may help elder adults stay physically strong for a longer period. ...

Health :Novel research may help older adults stay physically capable for longer

In a breakthrough study, researchers have identified a mechanism that drives the clearance of damaged mitochondria. The discovery can be considered to take researchers one step closer in the field of drug therapies that help older adults maintain the ...