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California [US], April 18 : UC Davis researchers are the first to describe how oligodendrocyte-lineage cells transfer cell material to neurons in the mouse brain. Their findings show that these cells and neurons interact in a coordinated nuclear manner.The findings of the study were published in the Journal of Experimental Medicine."This novel concept of material transfer to neurons opens new possibilities for understanding brain maturation and finding treatments for neurological conditions, such as Alzheimer's disease, cerebral palsy, Parkinson's and Huntington's disease," said corresponding author Olga Chechneva. Chechneva is an assistant project scientist at UC Davis Department of Biochemistry and Molecular Medicine and independent principal investigator in the Institute for Pediatric Regenerative Medicine at Shriners Children's Northern California.What are oligodendrocyte-lineage cells?Oligodendrocyte-lineage cells, also called oligodendroglia, are a type of glial cells found in the central nervous system. From birth onward, these glial cells arise to support neural circuit maturation. They are mostly known for their role in myelination - the formation of the insulating myelin sheath around nerve axons.Satellite oligodendrocytes are a distinct type of oligodendroglia found in close contact with neuronal bodies in the gray matter of the central nervous system. They are involved in several functions, including supporting the survival of nearby neurons, regulating neurotransmitter release, and modulating synaptic activity. They have a different form and structure than the classic oligodendrocytes that produce myelin in the white matter."Research has mostly focused on studying the myelinating function of oligodendrocytes, while satellite oligodendrocytes and their interaction with neurons are not well understood," Chechneva said.Unexpected observation makes a new discovery possibleCapturing the glia-neuron interaction started with an unexpected observation. The researchers were using special fluorescent proteins to label and track oligodendroglia in the mouse brain and spinal cord. They were surprised to find that ribosomal and nuclear reporter proteins were not only present in these cells, but also inside neurons of the mouse model."When something unexpected like this happens, we need to make sure it's not an artifact," Chechneva said. "It was puzzling why these proteins, which should only be in oligodendroglia, are also in neurons. Our team used different controls and did multiple experiments to conclude that oligodendrocytes transfer nuclear and ribosomal material to neurons."Open borders for material transferMaterial transfer of proteins and molecules from neuron to neuron and glia cells to neurons is critical to neuronal survival, function and recovery after injury.Until now, there were two known ways of material transfer in the neural system. The first is tunneling nanotubes or gap junctions, which are channels that allow for direct communication between cells. The other mechsm is through the release of extracellular vesicles (small structures that contain proteins, lipids, and nucleic acids). These vesicles can transfer various molecules that can be taken up by neighboring cells.This study is the first to capture and report on satellite oligodendrocytes found in contact with neurons that received material and with the plasma membrane between them interrupted."We are looking at the possibility of an additional new mechsm where the cell can directly transfer material to another cell, in particular satellite oligodendrocyte to neuron. We could clearly see that cell nuclei from both cells come together, and the plasma membrane (the physical border between cells) was open," Chechneva explained.Exploring the transfer mechsm for potential therapies to neurodegenerative diseasesThe study showed that oligodendroglia-neuron material transfer establishes after birth, during a critical period of brain maturation."The fact that this transfer process is established during postnatal development is very interesting. These are critical periods when the brain is maturing and brain circuits are formed," Chechneva said.The team still doesn't know the regulatory mechsm of material transfer or its duration."Our knowledge about this mechsm is extremely new, and it opens many questions for understanding how neurons work and its biological relevance in many neurological disorders. This is very exciting," Chechneva added.Disclaimer: This post has been auto-published from an agency feed without any modifications to the text and has not been reviewed by an editor

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Technology :Study finds how some brain cells transfer material to neurons

California [US], April 18 : UC Davis researchers are the first to describe how oligodendrocyte-lineage cells transfer cell material ... ...